The bug at Room 2100 in Dark Castle (first reported here) is still in the game, as Ron Burgundy found out on his epic run in season 28
Video:
Ron could probably have gone on even further but got Shrapnel shots in a hidden chest and the lag killed him. Until Lightheart adds a feature to decline a perk, there is a workaround to avoid taking a perk: you can restart the game. However, every subsequent hidden chest will give you the same perk, so it essentially means having to continue the run without hidden chests
Here’s some footage after taking Shrapnel:
And here’s the final perk build: